CXCR4 and acute myeloid leukemia: ,41,42,43 In our study, EMT-like or trans-differentiation signatures were correlated with CXCL12-CXCR4 signaling in inflammatory niches, suggesting a possible mechanism by which AML cells disseminate along the medullary-EM axis, consistent with recent findings implicating EMT pathways in EM AML progression.44