Several genes involved in immune regulation, inflammasome activity, and tumor progression, such as CD70, TMEM176B, TP53INP2, and TNFSF13B,20,21,22,23,24 were significantly enriched in the HLS spots in BM1, and these same genes were also highly expressed in the EM leukemic regions of the same patient (Figure S3G). This evidence concerns the gene TP53INP2 and neoplasm.