Beyond its structural function, loss of E-cadherin expression has been implicated in tumor progression and metastatic dissemination.7) Clinically, GI metastases from ILC are difficult to detect because of non-specific symptoms and lack of overt mucosal abnormalities in endoscopy.6,8) These lesions often appear submucosal or stenotic, mimicking primary GI tumors or even benign diseases. The gene discussed is CDH1; the disease is neoplasm.