Consistent with these features, both our patients exhibited the characteristic immunophenotype of metastatic ILC: CK7+, CK20–, GATA3+, CDX2–, and E-cadherin–, confirming the lobular origin and metastatic nature of the tumor.7) However, although this immunoprofile is highly suggestive of breast origin, it should not be considered pathognomonic. This evidence concerns the gene CDH1 and neoplasm.