Typical profiles of metastatic breast cancer include CK7+, CK20–, CDX2–, and GATA3+, with the loss of E-cadherin expression specifically supporting an ILC origin.9,10) Moreover, the receptor status may not always be congruent between primary and metastatic sites, further complicating diagnosis and treatment planning.11,12). The gene discussed is KRT7; the disease is breast carcinoma.