Moreover, decreased VAPB expression but no VAPB inclusions were detected in ALS8 patients’ iPSCs-derived motor neurons, and VAPB knock-out (KO) zebrafish and mouse models showed motor deficits, indicating that a loss-of-function mechanism might also be implicated in VAPB P56S’s pathogenicity in ALS[19,60,61]. The gene discussed is VAPB; the disease is amyotrophic lateral sclerosis.