The activation of DKK1 expressionby proinflammatory cytokines in rheumatoid arthritis maylead to the suppression of the Wnt signaling pathway and,consequently, the activation of the RANK/RANKL signalingpathway in osteoclasts, increasing their activity and causingthe bone loss characteristic of RA (Miao et al., 2013). The gene discussed is TNFSF11; the disease is rheumatoid arthritis.