To reproduce the state oftype 3 hemochromatosis, a virtual knockdown of TfR2 was performed, also by reducing the synthesis constant 100-fold.Numerical analysis revealed an increase in hepcidin concentrationand a decrease in ferroportin concentration, whichwas consistent with experimental data (Chua et al., 2010). This evidence concerns the gene SLC40A1 and hemochromatosis type 1.