MAPT and hippocampal atrophy: The core innovation of this study lies in integrating three different data dimensions: sMRI radiomics (RS), which directly reflects subtle brain structural damage (e.g., hippocampal atrophy, ventricular enlargement); clinical cognitive scales (Clinical), which quantify cognitive decline (e.g., memory, executive function); and plasma proteins (Protein), which capture molecular pathology (e.g., tau tangles).