In contrast, Late Relapse was linked to positive LVSI and larger tumor size (Fig. 5C). Tumor stage I preserved E-cadherin, and smaller tumor sizes acted as protective factors against Late Relapse, showing negative SHAP contributions that reduced the model's probability of Late Relapse and directed predictions toward No Relapse (Fig. 5D). Compared to the Traditional model, POLE exhibited a slight reweighting, highlighting the influence of size/LVSI for Late Relapse and cytology/CA125 for Early Relapse, while maintaining the early versus late pattern. The gene discussed is CDH1; the disease is neoplasm.