Wu et al. (2024) demonstrated that low Pre-Hb predicts postoperative infarction in moyamoya disease, while studies on intracerebral hemorrhage confirmed a linear relationship between decreased HB and adverse prognosis. These findings collectively underscore the clinical relevance of HB as a modifiable determinant influencing postoperative recovery, emphasizing that perioperative HB management may improve neurological outcomes (Acosta et al., 2021; Wu et al., 2024; Zhang et al., 2022). Here, GSTM1 is linked to intracerebral hemorrhage.