CTLA4 and hypopituitarism: Hypopituitarism onset has been reported at 8–16 weeks (95% CI) with anti-PD-1 antibodies [10], 0–48 weeks (95% CI) with anti-PD-L1 antibodies [10], and 4–10 weeks (95% CI) with anti-CTLA-4 antibodies [10].