Type 1 diabetes typically develops after a median of 4.5 courses (95% confidence interval [CI]: 1–17 courses) [8] with anti-PD-1 antibodies and 2.7 courses (95% CI: 1–5 courses) with anti-PD-L1 + anti-CTLA-4) [9]. The gene discussed is CTLA4; the disease is type 1 diabetes mellitus.