Additionally, G59S mutant p150Glued is less stable[20], and both G59S and Perry syndrome-related mutant p150Glued compromise normal functions of dynactin p150Glued in a dominant-negative fashion when overexpressed[13,14,21], suggesting a dominant-negative mechanism for DCTN1 mutation-induced neurodegeneration. The gene discussed is DCTN1; the disease is Perry syndrome.