DCTN1 and motor neuron disorder: As motor symptoms and weight loss are the main clinical manifestations in familial motor neuron disease and Perry syndrome cases with DCTN1 mutation[5], WT Tg, G59S Tg, G71R Tg mice, and their littermate controls were weighed, tested for locomotion activity in the open-field test, and examined for motor coordination in the rotarod test at 1, 6, 12, and 18 months of age.