Moreover, several members of the C1orf gene family—including C1orf61, C1orf222, C1orf158, C1orf87, C1orf167, and C1orf141—exhibited significantly differential expression between the two age groups, further supporting the age‐dependent transcriptional divergence in HBV‐related HCC (Figure 6G). Here, C1orf87 is linked to hepatocellular carcinoma.