Moreover, several members of the C1orf gene family—including C1orf61, C1orf222, C1orf158, C1orf87, C1orf167, and C1orf141—exhibited significantly differential expression between the two age groups, further supporting the age‐dependent transcriptional divergence in HBV‐related HCC (Figure 6G). This evidence concerns the gene C1orf167 and hepatocellular carcinoma.