Studies have reported that C1orf61 promoted HCC metastasis by inducing cellular epithelial‐mesenchymal transition (EMT) via the STAT3 and Akt cascade pathways, and elevated expression of C1orf61 has been associated with enhanced therapeutic efficacy of the anticancer agent sorafenib in patients with HCC [36]. This evidence concerns the gene MIR9-1HG and hepatocellular carcinoma.