APOE and dementia: In the study, we observed that while the absolute dementia risk for APOE ε4 carriers is similar across sexes compared to the specific baseline of non-carrier men (Table 4), there were significantly joint effects of the APOE ε4 and blood pressure metrics on dementia risk in exposed group compare to the nonexposed exposed in women and men (Table 5), resulting in an excess risk of 23% in the joint effect of APOE ε4 and ankle pressure to 46% in the joint effect of APOE ε4 and pulse pressure.