APOE and hypertensive disorder: In Table 3, Model 1 shows that individuals with hypertension (SBP/DBP ≥140/90 mm Hg), elevated brachial pressure, and those carrying the APOE ε4 allele in women, and in those with hypertension, elevated brachial pressure, decreased ABI, and those carrying the APOE ε4 allele in men had a significantly higher risk of dementia.