Abbreviations: BRAF V600E: B-Raf proto-oncogene, serine/threonine kinase (V600E mutation); GNA11: guanine nucleotide-binding protein subunit alpha-1; HMB-45: human melanoma black-45; MART-1: melanoma antigen recognized by T-cells 1; S100: S100 calcium-binding protein; SMA: smooth muscle actin. The gene discussed is MARK2; the disease is melanoma.