NPPB and heart failure: When ventricular myocytes sense increased wall stretch or stress, they release NT-proBNP, the N-terminal fragment of pro-BNP, in equal amounts to active BNP. NT-proBNP has a longer half-life and is more stable in plasma than BNP, which makes it easier to use in clinical diagnosis. Research indicates that NT-proBNP is associated with left-ventricular end-diastolic pressure and filling pressures, serving as a predictor of unfavorable outcomes in heart failure across various phenotypes [4-6].