Among CDX2-positive cases, an intestinal phenotype seems to be overrepresented and may mimic EMPD secondary to colorectal cancer, with no evidence of internal malignancy [31-34]; CDX2 can also be positive in secondary EMPD from colorectal origin and other primary cutaneous carcinomas, thus it should be used alongside other markers [34,35]. The gene discussed is CDX2; the disease is colorectal cancer.