TRPC3 and chronic myelogenous leukemia, BCR-ABL1 positive: Molecularly, endoplasmic reticulum stress induces macrophage apoptosis via the TRPC3 channel (deficiency of TRPC3 can significantly inhibit late-stage calcification) (86), while the CML/RAGE axis activates the BMP-2-Cbfα1-ALP calcification cascade by initiating apoptosis (87).