VWF and von Willebrand disease (hereditary or acquired): A Mendelian randomization study using 12,642 cases of VWD and 286,469 controls from the UK Biobank and FinnGen European ancestry cohort reported a reduced risk of endometriosis in individuals predicted to have higher levels of the metalloproteinase ADAMST-13, and thus lower levels of high-molecular-weight VWF multimers, based upon genetic markers, However, genetically predicted higher VWF plasma levels were associated with an increased risk of endometriosis [26].