In hepatocellular carcinoma (HCC), overexpression of HoxB5 transactivates the expression of downstream proteins, fibroblast growth factor receptor (FGFR) 4 and C-X-C motif chemokine ligand (CXCL) 1, leading to enhanced HCC metastasis [96]. This evidence concerns the gene HOXB5 and hepatocellular carcinoma.