Intrahepatic cholangiocarcinoma (iCCA), arising from the intrahepatic bile ducts, is enriched for alterations such as IDH1 mutations, FGFR2 fusions/rearrangements, BRAF V600E mutations, BAP1 loss, and microsatellite instability–high (MSI-H). Here, FGFR2 is linked to infantile convulsions and choreoathetosis.