Hyperactivation of MMSA-1/RAS/RAF signaling pathway made great changes of myeloma cells biological behaviors, including the stronger ability to proliferate, longer survival time, greater invasion and migration capabilities, as shown by the clonogenicity forming assay, Western Blot for key apoptosis factors, and mitochondrial apoptosis result as well as transwell assay results. Here, ZDHHC9 is linked to plasma cell myeloma.