Multiple Myeloma Specific Antigen-1 (MMSA-1) gene, also known as a novel splicing variant of ZDHHC9 gene, has been proved to be a multiple myeloma specific antigen which is relatively specifically overexpressed on myeloma cells and play important roles in myeloma cells proliferation, apoptosis and migration, as reported previously [3–5]. Here, ZDHHC9 is linked to AL amyloidosis.