As shown in Fig. 5C, the detected anti-apoptosis proteins BCL-2, BCL-XL level in MMSA−1+U266 cells were much higher than that in the other U266 cells while apoptosis inducing protein BAX was much lower in MMSA−1+U266 cells than that in the other cells, so as the great down regulation of Caspase family members in MMSA−1+U266 cells, all of which suggesting the MMSA-1’s proliferation promoting and anti-apoptosis ability in myeloma cells. The gene discussed is ZDHHC9; the disease is plasma cell myeloma.