To conclude, we revealed for the first-time myeloma specific antigen MMSA-1’s molecular regulation mechanism in MM as well as its biological function in promoting myeloma cells proliferation, apoptosis and its dissemination and invasion course, which greatly deepened our understanding of the biological function of MMSA-1 gene and provide a novel treatment target potential in the future. The gene discussed is ZDHHC9; the disease is plasma cell myeloma.