These changes in β-catenin signaling were accompanied by reduced expression of β-catenin target genes, including CyclinD1, c-Myc, SOX9, AXIN2, ABCG2, and c-jun, in both MHCC-97H and HCC-LM3 cells (Fig. 4E, F). This evidence concerns the gene CCND1 and hepatocellular carcinoma.