In our study, we identified two downregulated proteins that are of interest to the etiology of KC: superoxide dismutase 2 (SOD2) and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) after PPIP5K2 knockdown that may affect functional roles in the cornea or related to KC.47 Here, PPIP5K2 is linked to keratoconus.