MAPT and early-onset autosomal dominant Alzheimer disease: Several mutations in the Tau protein have been identified that contribute to a wide spectrum of Tauopathies, including Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) (Goedert and Jakes, 2005; Wolfe, 2009).