For example, recent compilations and analyses of proteomic data identified CCT components, TBCE, as well as Prefoldin subunits, including PFDN5, in AD tissue (Hsieh et al., 2019; Tao et al., 2020; Ji et al., 2022; Askenazi et al., 2023; Leitner et al., 2024; Sun et al., 2024). Here, TBCE is linked to Alzheimer disease.