PFDN5 and tauopathy: Moreover, our finding that neuronal expression of α-tubulin rescues the hTau-induced synaptic defects in a manner that critically requires Pfdn5 activity extends the functional requirement of Prefoldins in the suppression of Tauopathies beyond their reported activity in cell culture or in vitro models (Millán-Zambrano et al., 2013; Sörgjerd et al., 2013; Tashiro et al., 2013; Takano et al., 2014).