MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease, as well as a subset of other neurodegenerative disorders, together referred to as Tauopathies, are defined by accumulated intracellular aggregates of the Tubulin-associated unit (Tau) protein (Iqbal et al., 2010; Jouanne et al., 2017; Pinzi et al., 2023).