One metabolomic study in mice using a knock-in Fkrp line (FkrpP448L) to model a less severe form of dystroglycanopathy, Limb Girdle Muscular Dystrophy 2i (LGMD2i), identified global metabolic perturbations with increases in glycolytic intermediates and lipid metabolites [61]. The gene discussed is FKRP; the disease is neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.