FKRP and autosomal recessive limb-girdle muscular dystrophy type 2I: One metabolomic study in mice using a knock-in Fkrp line (FkrpP448L) to model a less severe form of dystroglycanopathy, Limb Girdle Muscular Dystrophy 2i (LGMD2i), identified global metabolic perturbations with increases in glycolytic intermediates and lipid metabolites [61].