This phenotype observed in miR-200a/b-resistant Zeb1 mice differs from the phenotype observed with complete loss of Lhb expression, which causes hypogonadism and infertility in both male and female mice [4], indicating that the small amount of circulating LH detected in female miR-200a/b-resistant Zeb1 mice is sufficient for gonadogenesis. This evidence concerns the gene LHB and hypogonadism.