BRAF and intracranial hemorrhage: Grade 5 adverse events consisted of intracranial hemorrhage (3 patients BRAF/MEKi and anti-programmed death-ligand 1 [aPD-(L)1]), central nervous system necrosis combined with intracranial hemorrhage (1 patient; BRAF/MEKi) and other or unknown (1 patient; aPD-(L)1) (eTable 1 and eTable 2 in Supplement 1).