Single-cell RNA-seq and IHC confirmed CAF-specific overexpression of DDR2 and SERPINF1.<h4>Conclusion</h4>The MBRG-based model effectively predicts BLCA prognosis, integrates mechanisms of basement membrane remodeling, EMT, and immune suppression, and identifies DDR2 and SERPINF1 in CAFs as potential targets for personalized therapy. Here, SERPINF1 is linked to bladder transitional cell carcinoma.