For the first time, the significant upregulation of the Fpn1-encoding gene and restoration of the SLC7A11/GPX4/GSH signaling pathway via modulating miRNA-367-3P expression represent a new mechanistic insight into KAM’s anti-ferroptotic and neuroprotective potential in the MOG35–55 peptide-induced EAE model of MS. Here, SLC7A11 is linked to myeloid sarcoma.