For example, ANXA5, VGF, GPM6A, and ACTZ were shown to differentiate AD‐derived brain EVs from controls with 88% accuracy via machine learning, and ANXA5 levels correlated with Braak stage, a widely used neuropathological classification that stratifies tau pathology from early transentorhinal involvement (I–II), through limbic stages (III–IV), to widespread neocortical pathology (V–VI), underscoring its diagnostic potential (Muraoka, DeLeo, et al. 2020). This evidence concerns the gene ANXA5 and Alzheimer disease.