Similar sex‐dependent patterns are observed in neurodegenerative conditions: in AD, the miRNA content of CSF‐derived EVs shows distinct signatures influenced by both sex and APOE‐e4 genotype, with females exhibiting higher levels of miR‐146b‐5p, miR‐150‐5p, and miR‐342‐3p, all linked to neuroinflammatory and autophagic pathways (Sandau et al. 2022). Here, APOE is linked to Alzheimer disease.