In a plasma EV study, the investigators identified seven upregulated proteins (FIBA, FIBB, FIBG, C09, VWF, LBP, and PRG‐4), with PRG‐4 correlating with preserved cognitive function in ALS patients, positioning it as a candidate biomarker for disease monitoring and a possible neuroprotective agent (Vilardo et al. 2024). Here, PRG4 is linked to amyotrophic lateral sclerosis.