In addition, iron accumulation in muscle cells has been shown to induce ferroptosis through p53 upregulation, which in turn downregulates a known ferroptosis gene SLC7A11 (encoding the protein xCT that can support GSH synthesis), leading to the accumulation of lipid peroxides, promoting muscle cell death and accelerating the progression of sarcopenia (Jiang et al. 2022). The gene discussed is SLC7A11; the disease is sarcopenia.