We used the conditions under which we had observed high viral loads with low variability paired with symptomatic disease: 7-week-old female C57BL/6 mice received 0.1 mg anti-IFNAR1 mAb (ip) followed by infection (ip) with 105TCID50 of CHIKV, MAYV or ONNV 48 h later. Here, IFNAR1 is linked to infection.