Indeed, while we previously found that fibronectin was a critical exosome cargo driving nascent adhesion formation, lamellipodia stabilization, and cell speed in HT1080 fibrosarcoma cells (Sung et al., 2015; Sung et al., 2011; Sinha et al., 2016), fibronectin was unable to rescue the filopodia defect of endoglin-KD HT1080 cells in this study (Fig. S7D). This evidence concerns the gene ENG and fibrosarcoma.