It would also be interesting to see whether THSD7A carried by EVs regulates kidney podocyte foot process formation downstream of filopodia and whether it is soluble proteolyzed THSD7A or THSD7A-carrying EVs released into the circulation by cancer cells that leads to autoimmune secondary membranous nephropathy (Herwig et al., 2019; Wang et al., 2019). This evidence concerns the gene THSD7A and membranous glomerulonephritis.