Interestingly, GFI1B loss also causes a macrothrombocytopenia phenotype in mice (Beauchemin et al., 2017), and in our data, TUBB1 expression decreases quickly as a function of decreased GFI1B expression but then plateaus at a level that corresponds to loss of one copy of TUBB1. Here, TUBB1 is linked to Macrothrombocytopenia.