Herein, we report two de novo variants (c.1311‐3C>G, c.347G>A (p.Arg116His)) and a novel de novo variant (c.346C>T (p.Arg116Cys)) in the SMARCC2 gene (NM_003075.3) in three Chinese patients with NDD (Figure 1B), and further provide a detailed description of the associated clinical features of these patients. This evidence concerns the gene SMARCC2 and Neurodevelopmental delay.