Conversely, when KLF4 functions as a tumor‐suppressive factor within the TME, as exemplified in lung adenocarcinoma, it downregulates NF‐κB2 and CXCR2, concomitantly restrains tumor cell invasion, and enhances the infiltration of CD4+ and CD8+ T cells, macrophages, and other immune subsets [34]. The gene discussed is CD8A; the disease is neoplasm.