Therefore, the net effect of KLF4 on MDSCs appears to be cancer‐type specific, largely dictated by the identity of the dominant chemokine downstream of KLF4 (CXCL5 vs. CXCL8), the upstream inflammatory signals within the TME, and the intrinsic role of KLF4 as either oncogene or tumor suppressor in the given tissue. Here, CXCL5 is linked to cancer.