Furthermore, KLF4 secreted by highly invasive CRC cells reinforces this immunosuppressive circuitry by simultaneously skewing TAMs toward an M2 state and upregulating PD‐L1 on TAMs, thereby inhibiting cytotoxic T lymphocyte (CTL) function, fostering T‐cell exhaustion, and facilitating immune evasion [129]. The gene discussed is KLF4; the disease is colorectal carcinoma.