Desulfovibrio, Desulfovibrionaceae, and Desulfovibrionales, all related to the Desulfovibrionaceae family, can produce hydrogen sulfide through sulfate-reducing metabolism, disrupt intestinal barrier integrity, and lead to the activation of pro-inflammatory signaling pathways such as NF-κB, which correlates with the type 2 immune shift in AD. The gene discussed is NFKB1; the disease is Alzheimer disease.