Similarly, another study (48) reported that Bifidobacterium longum subspecies infantis CCFM111 not only significantly suppressed IgE and type 2 cytokine expression (including IL-4, IL-13, and IL-6) in allergic rhinitis models but also increased the abundance of beneficial bacteria such as Akkermansia and Ruminiclostridium. The gene discussed is IGHE; the disease is allergic rhinitis.