These observations suggest that increased lncMGC in obesity conditions potentially modulates lncMGC/YBX1 interactions to (mis)regulate YBX1 function and/or expression, leading to altered brown adipocyte thermogenic function via PINK1/PRKN-mediated mitophagy.50 The gene discussed is PRKN; the disease is obesity due to melanocortin 4 receptor deficiency.