Our GSEA results indicated that high VPS35 expression was significantly associated with processes such as “homophilic cell adhesion via plasma membrane adhesion molecules” and “immunoglobulin receptor binding,” suggesting a potential role for VPS35 in recycling adhesion receptors (e.g., E-cadherin, integrins) or immune-related receptors, thereby influencing cell–cell interactions, metastasis, and immune modulation within the tumor microenvironment. This evidence concerns the gene VPS35 and neoplasm.