Notably, univariate Cox regression analysis indicated that the pathologic stage (HR = 2.50, 95% CI: 1.73–3.63, P < 0.001), pathologic T stage (HR = 2.60, 95% CI: 1.83–3.70, P < 0.001), pathologic M stage (HR = 4.08, 95% CI: 1.28–12.97, P = 0.017), tumor status (HR = 2.32, 95% CI: 1.59–3.38, P < 0.001) and VPS35 expression (HR = 1.64, 95% CI: 1.28–2.10, P < 0.001) were significantly associated with shorter OS in LIHC. The gene discussed is VPS35; the disease is neoplasm.