Mounting evidence indicates that the infiltrating immune cells within the tumor immune microenvironment (TIME) play crucial roles in tumor development and progression, thereby affecting the prognosis of tumor patients.37–39 In this study, we reported that VPS35 expression was significantly correlated with the infiltration of effector memory T cells (Tem), CD4 cells, Th2 cells, and immature dendritic (iDC) cells. Here, CD4 is linked to neoplasm.