VPS35 is a retromer protein primarily localized in endosomes and lysosomes,28 and it has been discovered that VPS35, as an essential structural component of the retromer complex, can regulate tumor growth and metastasis in liver and breast cancer by modulating multiple signaling pathways.25 However, the relationship between VPS35 and LIHC has not been comprehensively reported. The gene discussed is VPS35; the disease is breast cancer.