Our recent work [1] shows that kidney-specific SLC39A8 knockout (KKO) mice (reduced zinc uptake) exhibit milder AKI (ischemia–reperfusion and rhabdomyolysis) and CKD (ureteral obstruction and 5/6 nephrectomy), with lower serum creatinine/blood urea nitrogen (BUN) levels and reduced renal fibrosis. Here, SLC39A8 is linked to chronic kidney disease.