Nicolae and Ecaterina further reinforced the role of natriuretic peptides as markers of cardiopulmonary remodeling in elderly COPD patients, emphasizing their utility in identifying right heart strain even in the absence of overt cardiac disease [28]. Collectively, these studies, together with our findings, suggest that NT-proBNP measurement may augment clinical evaluation by reflecting the intersection of cardiac and pulmonary dysfunction in COPD. This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.