Conversely, the variants rs6756629 (chr 2-43837950-G-A, ABCG5) and rs11887534 (chr 2-43839107-G-C, ABCG8) exhibited strong negative correlations with LDL and DLCNC, indicating that these variants could be protective, potentially contributing to lower cholesterol levels and reduced FH risk. This evidence concerns the gene ABCG5 and familial hyperaldosteronism.