These include the use of hormonal oral contraceptives or hormone-secreting intrauterine device, postpartum period, and hypercoagulopathy conditions (methylenetetrahydrofolate reductase mutation, factor V Leiden, intense exercises, sarcoidosis, systemic lupus erythematosus, autoimmune hepatitis, Bechet’s disease, and use of tyrosine kinase inhibitor (sorafenib)). The gene discussed is MTHFR; the disease is systemic lupus erythematosus.