RA: rheumatoid arthritis, RAMRIS: rheumatoid arthritis magnetic resonance imaging score, CNNs: convolutional neural networks, ML: machine learning, RF: rheumatoid factor, ACPA: anti-citrullinated peptide antibodies, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, OA: osteoarthritis, KL: Kellgren-Lawrence, EHRs: electronic health records, SLE: systemic lupus erythematosus, anti-dsDNA: anti-double-stranded DNA antibodies, IHC: immunohistochemistry. The gene discussed is PRTN3; the disease is osteoarthritis.