However, DRE-associated PCa detection was significantly more frequent in the PSA < 3 ng/mL subgroup than between 3 and 4 ng/mL (24.6% vs. 8.8%; p = 0.044), with no corresponding difference in DRE-detected csPCa (p = 0.32). This evidence concerns the gene KLK3 and posterior cortical atrophy.