The infiltration of activated B cells, activated CD8 T cells, activated dendritic cells, effector memory CD4 T cells, gamma delta T cells, immature B cells, macrophages, myeloid-derived suppressor cells, natural killer T cells, neutrophils, type 17 T helper cells, and type 2 T helper cells were significantly higher in primary STS than in relapsed STS (supplementary Fig. 2E). This evidence concerns the gene CD4 and telomere syndrome.