The results showed that the concentrations of inflammatory factors in the colon tissue of colitis mice after oral gavage of A. actinomycetemcomitans were significantly higher than those in the DSS group (Il-6, P = 0.031; Il-1β, P = 0.005; Tnf-α, P < 0.0001) (Figure 5A). This evidence concerns the gene IL6 and colitis.