CHI3L1 and Alzheimer disease: However, in receiver operator characteristics analyses, neurogranin and YKL-40 used alone or in combination had a moderate diagnostic accuracy that was lower than that of the core AD biomarkers (amyloid-β<sub>42</sub>, total tau, and phosphorylated tau<sub>181</sub>).ConclusionsThis study shows that neurogranin and YKL-40 in CSF are elevated in MCI-AD compared with sMCI, and neurogranin was also higher in MCI-AD than in MCI-VaD.