Additionally, adenosine (ADO) has emerged as an immune checkpoint molecule that promotes tumor escape and can impair antitumor immune responses [21]; Tumor cells’ PD-L1 attaches itself to immune cells’ PD-1 surface to start the PD-1/PD-L1 immunosuppressive program in the tumor microenvironment [22, 23]; The NF-kB cascade, which is important for immune function, is probably necessary for antitumor immunity. Here, CD274 is linked to neoplasm.