NLRP3 and metabolic dysfunction-associated steatohepatitis: Several studies have demonstrated that NLRP3 is highly associated with MASH and liver fibrosis, and that the high expression of NLRP3 is primarily derived from MDMs [15, 16]. Transitioning macrophages from the M1 to M2 state can suppress pyroptosis by downregulating the NLRP3 inflammasome and related pathways [17].