LGALS3 and Alzheimer disease: Furthermore, in precursor conditions of AD, including atherosclerosis, aortic aneurysm, and hypertension-induced vascular remodeling, MCP inhibits Gal-3-mediated endothelial dysfunction, Mφ-driven inflammation, and ECM degradation, highlighting its potential to stabilize the aortic wall, prevent dissection, and mitigate long-term vascular remodeling [31].